翻訳と辞書 Words near each other ・ Mir-14 microRNA precursor family ・ Mir-143 ・ MiR-144 ・ Mir-145 ・ MiR-146 ・ Mir-148/mir-152 microRNA precursor family ・ Mir-15 microRNA precursor family ・ MiR-150 ・ Mir-153 microRNA precursor family ・ Mir-154 microRNA precursor family ・ MiR-155 ・ Mir-156 microRNA precursor ・ Mir-16 microRNA precursor family ・ Mir-160 microRNA precursor family ・ Mir-166 microRNA precursor ・ Mir-17 microRNA precursor family ・ Mir-172 microRNA precursor family ・ Mir-181 microRNA precursor ・ Mir-184 ・ Mir-185 microRNA precursor family ・ Mir-186 microRNA precursor family ・ Mir-187 microRNA precursor family ・ Mir-188 microRNA precursor family ・ Mir-19 microRNA precursor family ・ Mir-190 microRNA precursor family ・ MiR-191 ・ Mir-192/215 microRNA precursor ・ Mir-193 microRNA precursor family ・ Mir-194 microRNA precursor family ・ Mir-196 microRNA precursor family Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Mir-17 microRNA precursor family ： ウィキペディア英語版 Mir-17 microRNA precursor family The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b. With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families. These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA. The paralogous miRNA gene clusters that give rise to miR-17 family microRNAs (miR-17~92, miR-106a~363, and miR-106b~25) have been implicated in a wide variety of malignancies and are sometimes referred to as oncomirs. The oncogenic potential of these non-protein encoding genes was first identified in mouse viral tumorigenesis screens. In humans, the activating mutations of miR-17~92 have been identified in non-Hodgkin's lymphoma, whereas the miRNA constituents of the clusters are overexpressed in a multiple cancer types. High level expression of miR-17 family members induces cell proliferation, whereas deletion of the miR-17~92 cluster, in mice, is lethal and causes lung and lymphoid cell developmental defects. In addition, in the nasopharyngeal carcinoma cell line, miR-20a and miR-20b has been shown to target the 3’ UTR of vascular endothelial growth factor (VEGF) and repress the expression of VEGF, which is an important angiogenic factor. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Mir-17 microRNA precursor family」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.